UAB gets NFL grant to study concussions - ABC 33/40 - Birmingham News, Weather, Sports

UAB gets NFL grant to study concussions

Posted: Updated:
Dr. Candace Floyd/uab.edu Dr. Candace Floyd/uab.edu

NFL Charities, a non-profit foundation created by the league owners, is giving a team of researches at UAB a portion of a $1.5 million grant package to study a new compound that may minimize the effects of concussions.

Dr. Candace Floyd, the associate professor and director of research in the Department of Physical Medicine and Research at UAB, and Dr. Hubert Tse, assistant professor in the Department of Microbiology, will lead a team in studying a compound known as a catalytic oxidoreductant, which may lessen the secondary effects of concussions.

According to Floyd, when a concussion occurs the brain suffers mechanical injury at the moment of initial impact, in which brain cells are damaged by the force of the impact.  This is followed by an array of biochemical injuries, including "oxidative stress and an overly aggressive immune response to inflammation in the brain."

"A good analogy might be a small forest fire," says Floyd. "The original concussive impact creates a small fire that by itself only causes minimal damage to the forest. But if the body's response to that fire is inappropriate and too strong, it fans the flames and causes the fire to burn out of control. We believe our experimental compound (catalytic oxidoreductant) will shut off that response, minimizing the damage while allowing the fire to burn out on its own."

Originally, the compound, developed by Dr. Tse in collaboration with colleagues at Duke University, was created to combat rejection in organ transplants.  Floyd and other doctors noticed the positive effects it was having on reducing oxidative stress which led to a new pilot study on spinal cord injuries.  That study exhibited encouraging signs, resulting in the new concussion study.

"We're very glad to be working with NFL Charities on this novel approach to minimizing the injuries associated with concussions," says Floyd. "Our share of the funding, $100,000 over the next year and a half, will allow us to ascertain the validity of this very promising approach."

The team will also study the compound's effects on numerous concussions due to the growing evidence of significant brain damage resulting from three or more concussions.  Floyd says the goal would be to have a drug that can be given to the patient immediately following a concussion, whether it be by a trainer on a football field or EMS at the site of a car accident.

 

 

  • Birmingham Area NewsMore>>

  • UPDATE: Crews restore water service in Birmingham's Norwood area

    UPDATE: Crews restore water service in Birmingham's Norwood area

    Monday, September 1 2014 2:04 AM EDT2014-09-01 06:04:24 GMT
    Crews with the Birmingham waters board are still trying to fix a water main break that erupted yesterday in the Norwood area. According to spokeswoman Binnie Myles the break involves a 20 inch main sandwiched in between two gas lines.More >>
    Crews with the Birmingham waters board are still trying to fix a water main break that erupted yesterday in the Norwood area. According to spokeswoman Binnie Myles the break involves a 20 inch main sandwiched in between two gas lines.More >>
  • Car crashes into Birmingham house

    Car crashes into Birmingham house

    Sunday, August 31 2014 10:18 PM EDT2014-09-01 02:18:57 GMT
    Neighbors living on 16th Way Southwest in Birmingham say they're dealing with a serious problem.Numerous accidents are happening around a dangerous curve.Sunday a car slammed into a house.Neighbors say no one was hurt. But there are many concerns."I was wondering was I going to run or duck, was it going to hit our home." But a dodge charger hit the house across the street from Marcus Yarbrough's house. "I heard the car coming, screeching around the corner." "Instead of having a head on collis...More >>
    Neighbors living on 16th Way Southwest in Birmingham say they're dealing with a serious problem.Numerous accidents are happening around a dangerous curve.Sunday a car slammed into a house.Neighbors say no one was hurt. But there are many concerns."I was wondering was I going to run or duck, was it going to hit our home." But a dodge charger hit the house across the street from Marcus Yarbrough's house. "I heard the car coming, screeching around the corner." "Instead of having a head on collis...More >>
  • No more parking under I-20/59 bridges starting Tuesday

    No more parking under I-20/59 bridges starting Tuesday

    Sunday, August 31 2014 9:29 PM EDT2014-09-01 01:29:44 GMT
    Starting this Tuesday, parking spots under the Interstate 20/59 bridges near the BJCC in downtown Birmingham will be eliminated. Crews have put up at least one large sign, warning drivers of the change. SomeMore >>
    Starting this Tuesday, parking spots under the Interstate 20/59 bridges near the BJCC in downtown Birmingham will be eliminated. Crews have put up at least one large sign, warning drivers of the change. SomeMore >>
  • Anniston - Gadsden Area NewsMore>>

  • Arrest made in large level extortion scheme

    Arrest made in large level extortion scheme

    Friday, August 29 2014 12:45 PM EDT2014-08-29 16:45:16 GMT
    "Everett Leon Stout, 72 and Miriam Clair Schultz, 67 are charged with 14 counts of extortion.More >>
    "Everett Leon Stout, 72 and Miriam Clair Schultz, 67 are charged with 14 counts of extortion.More >>
  • Gadsden police recover more than 300 stolen items; felony charges against suspected fence

    Gadsden police recover more than 300 stolen items; felony charges against suspected fence

    Thursday, August 28 2014 11:22 PM EDT2014-08-29 03:22:34 GMT
    Joe Walker Pearl (Photo: Etowah County Sheriff's Office)Joe Walker Pearl (Photo: Etowah County Sheriff's Office)
    Police in Gadsden are trying to return hundreds of stolen items to their rightful owners. Captain Paul Cody said officers bust a large fencing operation this week. Joe Pearl, 75, is the suspect in the case. It took a long time to sort through and document a very wide range of stolen property. "We've collected a lot of stuff," Cody said. "Toilet paper. We have non-firearms related weapons, we have karaoke machines, musical instruments, car stereos, underwear."More >>
    Police in Gadsden are trying to return hundreds of stolen items to their rightful owners. Captain Paul Cody said officers bust a large fencing operation this week. Joe Pearl, 75, is the suspect in the case. It took a long time to sort through and document a very wide range of stolen property. "We've collected a lot of stuff," Cody said. "Toilet paper. We have non-firearms related weapons, we have karaoke machines, musical instruments, car stereos, underwear."More >>
  • Gadsden police arrest suspect in deadly stabbing case

    Gadsden police arrest suspect in deadly stabbing case

    Thursday, August 28 2014 11:37 AM EDT2014-08-28 15:37:31 GMT
    William D'Angelo McKinney (Photo: Etowah County Sheriff's Office)William D'Angelo McKinney (Photo: Etowah County Sheriff's Office)
    Investigators in Gadsden said a man strangled his ex-girlfriend Tuesday evening before stabbing another man to death. Officers arrested 30-year-old William D'Angelo McKinney Wednesday night. He faces charges for murder and domestic violence with strangulation. Police said McKinney went to his ex-girlfriend's home in the Mill Village area and let himself in. Investigators said she asked him to leave, but he shoved her and then put her in a headlock until she blacked out.More >>
    Investigators in Gadsden said a man strangled his ex-girlfriend Tuesday evening before stabbing another man to death. Officers arrested 30-year-old William D'Angelo McKinney Wednesday night. He faces charges for murder and domestic violence with strangulation. Police said McKinney went to his ex-girlfriend's home in the Mill Village area and let himself in. Investigators said she asked him to leave, but he shoved her and then put her in a headlock until she blacked out.More >>
Most Popular
Stories
Videos
loading...